In-vitro Anticancer and Cytotoxic Activity of Ginger Extract on Human Breast Cell Lines

Abstract

Breast cancer is the leading cause of cancer related mortality in women. Breast cancer is highly
metastatic and can spread to various parts of the body.Ginger,the rhizome of Zingiber officinale,
one of the most widely used species of the ginger family, is a common condiment for various
foods and beverages. Ginger has a long history of medicinal use. The aim of this study was to
evaluate the effect of in vitro anticancer and cytotoxic activity of ginger ethalonic extract against
breast cancer cell lines using MTT assay method. Results revealed that ginger extract possesses
dose dependent cytotoxic effects on breast cancer cell lines.Whereas, IC50 values for 48hours of
treatment found to be 9.68 mg/l, 2.47 mg/l and 12.81 mg/l on MCF-7,MDA-MB-231 breast cancer
cell lines and non-tumorigenic, normal breast epithelial MCF-10A cell line, respectively with
relatively high selectivity ( SI= 5.1) against MDA-MB231. It could be concluded and recommended
that ginger exhibits anticancer activity on breast cancer cell lines, hence ginger can be further
evaluated for potential promising anticancer activity.