Glioblastoma multiforme in a 12 years old boy

Kamal Eldein Hamed Mohamed, Salah Osman Salah


This is a rare case of a ft twelve-year-old male child, who presented with headache and convulsions.
MRI showed 5x5 cm right tempro-parietal mass. Surgery was performed, and histopathology and immunehistochemistry confrmed the diagnosis of gliobastoma multiforme. He received external beam radiotherapy
in a dose of 54 Gy in 27 fractions, concomitant with daily oral Temozulamide, followed by adjuvant monthly Temozulamide for six months. He remained well and died two and half years after treatment due to disease

Full Text:



Reddy AT, Wellons JC. Paediatric high grade

gliomas. The Cancer J.2003; 9:107 -112.

Tamber BMS, Rutka JT. Paediatric

supratentorial high grade gliomas.Neurosurgery


Marina S, Yacob, Donna Johnson. Gliobalstoam

Multiforme a paediatric case series. J of Case

Reports and Images in Oncology. Article ID:


Dropcho EJ, Wisoff JH, Walker RW, Allen JC.

Supratentorial malignant gliomas in childhood,

a review of cases. Am J of Neurol. 1987;


Chang YW, Yoon HK, Shin HJ, Boh HG,

Cho JM. MRI in glioblastoma multiforme

in children usefulness of diffusion/perfusion

weighted MRI and MRI spectroscopy. Pediat

Radiol J. 2003; 33:836—842.

Wolff B, Ng A, Roth D, Partthey K. Paediatric

high grade gliomas of the spinal cord, results of

the HIG-GBM data base. J of Neurooncology.


Song KS, Phi JH, Cho BK, Wang KL. Long term

outcome of children with GBM. J Neurosurg

Pediat. 2010; 6:145—149.

Fangusaro J. Review: Paediatric high grade

gliomas and diffuse intrinsic pontine gliomas. J

of childhood Neural. 2009; 24:1402--1417.

Spoto R, ErtelI J, Jenkin RD, Boesel LP. The

effectiveness of chemotherapy in treatment of

high grade gliomas in children, randomized

study. J of Neuro oncology.2005; 7:165—177.

Finlay L, Boyet JM, Yates A, Wisoff JH.

Randomized phase three trial in children with

high grade gliomas comparing vincristine,

lomustine and prednisolone with the eight in

one in one day regimen, children cancer group

study. J Cln Oncol.1995; 13:112—123.

Morris PG. Bevacizumab an active agent for

recurrent high grade gliomas, do we need

randomized trials. Anti Cancer Drugs.2012;


Gurrangen S, Chi SN, Young Poussiant T,

Omar-Thomas A. Trial of Bevacizumab

and irinotican in children with malignant

gliomas and diffuse brain stem gliomas. J Clin

Oncol.2010; 28:3069—3075.

Supriya Malick, Ajeet Kumar, NikilLp, Joshi.

The Indian J of Medical and Paediatric

Oncology 2015; 38 :99—104.

Mansour Asari, Hamid Nasroalahi, Amir Abbas

Kani. Paediatrics GBM a single institution

experience. The Indian J of Medical and

Paediatrics Oncology 2012,34 pmc 3513472.

Perkin MD, Gagal S, Pinkawa M. GBM in

children: a single institution experience. Int J

of Oncol Biol and Physics.2011; 80:117—121


  • There are currently no refbacks.

ISSN: 1858-5345