Effect of propolis on reproductive hormones of selective serotonin reuptake inhibitors (SSRIS)-induced sexual dysfunction in male wistar rats

T.O. Ayinde, M.M. Kardash, H.M. Abdulwahab, M.B. Hind, M.O. Hussien

Abstract


Background   It is estimated that up to 50-80% of patients who take SSRIs suffer from post-SSRIs sexual dysfunction which affects the self esteem of victims. Invariably, it is often claimed to be intervened locally by different concoctions. Propolis is a mixture collected by honey bees from parts of plants, and indeed being exhibited now as “natural” sexual enhancer. The present study aimed at exploring the medicinal activities of propolis on alterations in level of reproductive hormones which are key players in assessment of sexual dysfunction.
Methods Sexually potent male wistar rats (140-190g), and equal number of sexually unexposed females (120-130g) were used for this study. They were then randomly divided into 8 groups of six rats each (n=6) after induction of sexual dysfunction with oral 10mg/kg b.w. paroxetine hydrochloride for 2 weeks in groups III-VIII. Sexual dysfunction was confirmed through copulatory test with females. Group I was treated with normal saline (control), group II was given propolis, group III was left untreated, group IV was given  sildenafil, while groups V-VIII were given graded concentrations of propolis, all over a duration of  60 days. Following this, the animals were sacrificed, and blood samples collected for biochemical analysis of LH, FSH and testosterone.
Results The LH result showed that there was significant (p<0.05) increase in propolis-sildenafil combination treated rats, and significant (p<0.05) reduction in other propolis administered rats, paroxetine untreated rats, and sildenafil treated rats when compared to control. The FSH levels of non-induced propolis-administered rats and propolis-sildenafil combination treated rats exhibited significant (p<0.05) increase when compared to control group. While there was significant (p<0.05) reduction in paroxetine-induced untreated rats, all other treated groups were not statistically significant (p>0.05) compared to control. Significant (p<0.05) reductions in testosterone level were observed in paroxetine-induced untreated rats and high dose propolistreated rats. However, all other propolis-administered rats and sildenafil-treated rats were not significantly (p>0.05) different from the control.
Conclusion Propolis has a key role to play in reproductive functions in enhancing sexual ability if given at different appropriate doses and timing in post-SSRIs sexual dysfunction, perhaps through modulation of reproductive hormones in the hypothalamus-pituitary-testicular axis.

Keywords


Effect of propolis on reproductive hormones;selective serotonin reuptake inhibitors ;SSRIS;induced sexual dysfunction; male wistar rats

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References


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Effect of propolis on reproductive hormones of selective serotonin reuptake inhibitors (SSRIS)-induced sexual dysfunction in male wistar rats

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