The honeymoon phase in Sudanese children with type 1 diabetes mellitus

Intisar A Khider, Mariam Z Mubarak, Ilham M Omer, Mohamed A Abdalla


Background  The honeymoon period (HP) refers to the period of time shortly after the diagnosis of type 1 diabetes mellitus (T1DM), during which there is some  restoration of insulin production by the pancreas, a temporary phase during which there is glycemic control and with longer period there is chance to delay potential complications. Recently researches focused on prolongation or permanence of the period. However very limited data is available in literature and this is the first study from Sudan.   
Objectives to a) investigate for the frequency of occurrence of the HP among Sudanese diabetic children, b) study its onset, duration and influential factors, c) recognize potential impacts and family attitude after the honeymoon period gets over   and d) assess doctors attitude during  HP.
Methods This is a cross-sectional hospital-based study on HP among children with T1DM in three specialized diabetic clinics in Khartoum State. Those who presented during the period June-Sept 2011were included and data was collected using personal interviews.  
Results A total of 136 patients with T1DM were enrolled; 26(19.1%) of them experienced the HP; 15(57.7%) were males and 11(42.3%) were females. The duration of time from the onset of DM till remission was 3.2 ± 6.3 (mean ± SD) months. Twenty two (84.6%) patients recognized the HP through low blood glucose level, 4(15.4%) had frequent attacks of hypoglycemia and decreased insulin requirements. The mean duration of the HP was 5.4 ± 12.9 months. Insulin requirements were 0.4 U/kg/day in 14(53.8%) patients during the HP while 0.5-0.7 U/kg/day was needed in 13(55.6%) patients after recovery. Age of onset was below 5 years in 7(26.9 %) patients while 19(73.1%) patients were 5 years and above. HBA1c measurements, 3 months after the HP were 5.8-6.1 % in 15(62.5%) patients,   5.4-5.7% in 4(16.8%) and 5-5.3% in 5(20.8%) patients. Conclusion Sudanese children with T1DM experience HP in a frequency lower than that recorded in other countries.


The honeymoon phase;Sudanese children;diabetes mellitus

Full Text:



Kevan C Herold, Williams Hagopian M, Julie A Auger, et al. Monoclonal antibody in neoonset Type 1 Diabetes Mellitus. N Engl J Med 2002;346:1692-1698. 2. Buyukgebiz A, Cemeroglu AP, Bober E, Mohn A, Chiarelli F. Factors influencing Remission Phase in children with Type 1 Diabetes Mellitus. J Paediatr Endocrinol Metabol 2011;14(9):1585-1596. 3. Fran Cogen. Health Central. My Diabetes: The Honeymoon Period in Type 1 Diabetes, December 08, 2009. http://www.healthcentral. com/diabetes/c/651 280 /index/44 4. Moole H, Moole V, Mamidipalli A, et al. Community Hosp Intern. Spontaneous complete remission of Type 1 Diabetes Mellitus in an adult - review and case report. Med Perspect 2015;5(5):28709.

Stamper IJ, Jackson E, Wang X. Phys Rev E Stat Nonlin Soft Matte Phase transitions in pancreatic islet cellular networks and implications for Type 1 Diabetes. Physical Review E 2014;89(1):012719. 6. Muhammad B Jan, Peter G F Swift, Neil T Raymond, Johannes L Botha. Partial remission phase of diabetes in children younger than age 10 years. Arch Dis Child 1999;80:367-369. 7. Henrik B Mortenson, Philip Hongaard, Peter Swift et al. Study group on childhood diabetes: new definition for partial remission period in children and adolescents with T1DM. Diabetes Care 2009;32(8):1384 -1390. 8. Henrik B Mortensen, Drmedsci Philip Hougaard Drsci, Peter Swift, et al. Factors contributing to partial remission in Type 1 Diabetes: analysis based on the insulin dose-adjusted HbA1c in 3657 children and adolescents from Germany and Austria. Pediatr Diabetes 2016.doi:10.1111/pedi.12413. 9. Hamdy NM. Pharmacist guide to understanding Type 1 Diabetes in childhood. Lecture for Dept of Biochemistry, Ain Shams University 15 July 2008. php 10. Brod S, Orlander P, Lavis V, et al. Ingested IFN-a prolongs the honeymoon period in newly diagnosed Type 1 Diabetes Mellitus. J Interferon Cyt Res 2001;21(11):102-103. 11.

Abdul-Rasoul M, Habib H, Al-Khouly M. ‘The honeymoon phase’ in children with Type 1 Diabetes Mellitus: frequency, duration, and influential factors. Paediatr Diabetes 2006;7(2):101-7. 12. Stephen Gitelman. New diabetes treatments aim for Never Ending Honeymoon. Feb23/2011. http;// diabetes. 13. Lombardo F1, Valenzise M, Wasniewska M, et al. Two-year prospective evaluation of the factors affecting honeymoon frequency and duration

The honeymoon phase in Sudanese children with type 1 diabetes mellitus

in children with insulin dependent diabetes mellitus: the key-role of age at diagnosis. Diabetes Nutr Metab 2002;15(4):246-51. 14. Naweed Alzaman, Richard D Siegel, Ernst John Schaefer. Endocrine Society’s 96th Annual Meeting and Expo, June 21–24, 2014 - Chicago SUN-0974: Prolonged honeymoon period in Type 1 Diabetic patients with Low Carbohydrate Intake 3 1Tufts Med Ctr, Boston, MA 2Tufts Medical Center, Medford, MA 3JM USDA HNRCA at Tufts University, Boston, MA: http:// DGM.6. SUN-0974#sthash. FSRv75o1.dpuf. › endo › webprogram › Session4807


  • There are currently no refbacks.

ISSN: 1858-5345