Non Hodgkin’s lymphoma and its association with Hepatitis C (HCV) and Human Immune Deficiency Viruses (HIV) in Sudanese patients

Nagla Gasmelseed, Afrah Awad Elsir, Ahmed Elhaj Mohamed

Abstract


Background: Lymphomas constitute a heterogeneous group of malignant disorders with different
clinical behaviours, pathological features and epidemiological characteristics. Infections with certain
viruses and bacteria are associated with increased risk for lymphomas.
Objectives: The objective of this study was to identify the association of HCV, HIV and Non Hodgkin’s
lymphoma (NHL) in the Sudanese.
Patients and Methods: A case-control study was conducted at the National Cancer Institute (NCI)
University of Gezira Sudan, during 2007 to 2008. HCV and HIV were detected using polymerase chain
reaction (PCR), in 81 NHL patients (confirmed cytologically and histopathologically) and 95 hospitalbased
controls matched for sex and age. ICT was used as a screening method for both HCV and HIV.
Results: HCV was identified in 3 (3.7%) cases and 3 (3.2%) controls. The difference was not significant.
9/81 (11.1%) cases and 2/95 (2.1%) of the controls were found positive to HIV. The result showed a
significant difference between cases and controls (P<0.05).
Conclusion: HIV infection, but not HCV infection, was associated with non-Hodgkin’s lymphoma in
Sudanese, suggesting a possible role for HIV in the development of non-Hodgkin’s lymphoma.

Keywords


Non Hodgkin’s; lymphoma and its ;association with ;Hepatitis C (HCV) and; Human; Immune; Deficiency ;Viruses (HIV) in ;Sudanese; patients

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