Review Article: The role of Neo adjuvant Chemotherapy in the treatment of Breast Cancer

Kamal Eldein Hamed Mohamed, Muna Mohamed Ahmed Kaboush, Abdelsamie Abdalla Mohamed


Neoadjuvant chemotherapy (NACT) in breast cancer is giving chemotherapy before surgery, it’s an effective
initial treatment for large tumors, locally advanced cancer and inflammatory breast cancer. It downstage
the disease, allow lesser extensive surgery e.g. breast conservative surgery, the benefit is greater for those
who attain pathological complete response (PCR), who get a significantly better overall survival (OS), and
progression free survival (PFS), compared with those who don’t. This approach is very important in Sudan
where the majority, almost 65 % of patients present with locally advanced disease, most of them are denied
this treatment.


The role ;Neo adjuvant ;Chemotherapy ; treatment ;Breast Cancer

Full Text:



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