Clinico-pathological features of breast cancer in patients below 50 years of age in Khartoum

Eltaib A. M. Saad, Randa Zaki A. Khair

Abstract


Background: The    burden    of    breast    cancer    is    high    among    all    age    groups    but    younger    age    groups    have    recently    shown    a    distinct    pattern    of    presentation.    
Objective: This    study    describes    the    clinicopathological    features    of    breast    cancer    among    Sudanese    patients    below    the    age    of    fifty    who    presented    with    breast    cancer    to    the    University    Of    Khartoum    Surgical    Unit    (USU)    in    Khartoum    Teaching    Hospital    (KTH).
Patients and Methods:    This    is    a    descriptive    analytical    hospital-based    study.    Data    was    collected    by    reviewing    medical    records    of    a    total    number    of    292    female    patients    who    presented    to    USU    with    breast    cancer    from    January    2010    to    December    2014.
Results:     A    total    number    of    292    patients    of    breast    cancers    were    included.    Of    these    177(60.6%)    were    below    the    age    of    fifty.    Analysis    of    below    fifty    years    group    showed    that    the    majority    of    them    were    multiparous    (78%).    The    lag    time    between    the    initial    complaint    and    presentation    was    3-6    months    in    55%.    Ninety    nine    (56%)    presented    with    locally    advanced    breast    cancer    (stage    III),    while    17%    had    metastatic    cancer    at    the    time    of    presentation,    and    27%    presented    with    early    breast    cancer    (stage    I&II).    Histopathological    results    showed    invasive    ductal    carcinoma    in    161(91.5%)    patients,    and    the    majority    14481.5%) )    were    poorly    differentiated    tumors.    Estrogen    receptor    (ER)    status    was    negative    in    106    (60%)    patients.    
Conclusion: Breast    cancer    amongst    Sudanese    patients    who    are    younger    than    50    years    is    characterized    by    a    triad    of    longer    lag    time    (>3    months)    between    the    initial    complaint    and    presentation,    advanced    clinical    stages    at    the    time    of    presentation    (stages    III&IV)    and    aggressive    histopathological    features    (poor    differentiation    and    negative    ER).    The    majority    of    patients    are    multiparous    and    premenopausal.

Keywords


Clinico-pathological features ;breast cancer in patients ;below 50 years of age

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