Haemoglobin A1c level in non-diabetic patients with end- stage renal disease on haemodialysis

Abstract

Background: Haemoglobin A1c(HbA1c) is widely used to monitor the glycaemic control in diabetic
patients. Recently, it has been found useful for the diagnosis of diabetes mellitus. High HbA1c is said to be
associated with high risk of coronary vessel disease irrespective of diabetes.
Objectives: to measure HbA1c concentration in patients with end-stage renal disease on haemodialysis
and to correlate its concentration with the duration of disease and total cholesterol level.
Methods: sixty non-diabetic patients with end-stage renal disease on haemodialysis were included in the
study. They were matched for sex and gender with sixty apparently normal controls.
Results: there was a significant increase in HbA1c concentration in the study group when compared with
the controls with a mean HbA1c concentration of 5.67% +0.2 (P-value= 0.000). There was a significant
positive correlation between the HbA1c level and the duration of the haemodialysis (p-value<0.05). A
strong correlation was found between Hb A1c and the total cholesterol concentration (p-value< 0.05).
Conclusion: Hb A1c is higher in patients with end-stage renal disease when compared with normal
controls. The increase in HbA1c correlates with the duration of the haemodialysis and the cholesterol level.